The Cheré Botha School was established by Mike and Gloria Botha in 1981 and named  in memory of their daughter Cheré who was born on 17 September 1976 with Down’s Syndrome and sadly, died of leukemia on 27 June 1980.

The official opening of the school took place on 17 September 1981.

The school was originally part of the Down’s Syndrome Association of the Western Cape, but now falls under the Western Cape Department of Education.